Rosemary Kennedy lobotomy.

Rosemary since birth has had major developmental setbacks due to being held in the womb for up to two hours. Not enough oxygen to her brain. Her mother was instructed to hold Rosemary in, because the Doctor was running late, and was apparently busy dealing with people suffering from the Spanish Flu.

In 1938, Rosemary was presented to King George VI, and Queen Elizabeth.

After that visit to the UK, Wikipedia says that Rosemary started regressing big time, violent outbursts, depression, rebellion. She was having many sexual partnerships, and her family feared that she would get pregnant or get an STD. So her dad decided to get her a lobotomy in 1941.

She was the disposable slightly mentally disabled spawn whom ole Joe probably eagerly offered up in exchange for favors.